The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

The evolutionary origin of metazoan cell types such as neurons and muscles is not known.
Using whole-body single-cell RNA sequencing in a sponge, an animal without nervous …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

The Islets of Langerhans are crucial 'micro-organs' embedded in the glandular exocrine
pancreas that regulate nutrient metabolism. They not only synthesize, but also secrete …

Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this
study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer …

Over the last decade, it has been discovered that the transcription factor Sox9 plays several
critical roles in governing the development of the embryonic pancreas and the homeostasis …

Neoplastic transformation requires changes in cellular identity. Emerging evidence
increasingly points to cellular reprogramming, a process during which fully differentiated and …

Pancreatic ductal adenocarcinomas comprise a hierarchy of tumor cells that develop around
a population of cancer stem cells. The cancer stem cells promote tumor growth and …

Pancreatic ductal metaplasia (PDM) is the transformation of potentially many type of cells in
pancreas into ductal or ductal-like cells, which eventually replace the existing differentiated …