Molecular mechanisms and emerging therapeutics for osteoporosis
JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …
that more than 10 million people in the United States and 200 million men and women …
Estrogens and androgens in skeletal physiology and pathophysiology
M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Nature genetics, 2009 - nature.com
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …
Genetics of osteoporosis
SH Ralston, AG Uitterlinden - Endocrine reviews, 2010 - academic.oup.com
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …
Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives
X Lin, D Xiong, YQ Peng, ZF Sheng… - … interventions in aging, 2015 - Taylor & Francis
With the progressive aging of the population, osteoporosis has gradually grown into a global
health problem for men and women aged 50 years and older because of its consequences …
health problem for men and women aged 50 years and older because of its consequences …
Genetics of osteoporosis from genome-wide association studies: advances and challenges
Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …
prevalence owing to the ageing of our global population. Clinically defined largely through …
Genome-wide association with bone mass and geometry in the Framingham Heart Study
Background Osteoporosis is characterized by low bone mass and compromised bone
structure, heritable traits that contribute to fracture risk. There have been no genome-wide …
structure, heritable traits that contribute to fracture risk. There have been no genome-wide …
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits
Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons.
Genome-wide association studies (GWAS) have become an unbiased approach to identify …
Genome-wide association studies (GWAS) have become an unbiased approach to identify …
Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
Many positive signalling pathways of osteoclastogenesis have been characterized, but
negative signalling pathways are less well studied. Here we show by microarray and RNAi …
negative signalling pathways are less well studied. Here we show by microarray and RNAi …
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies
Bone mineral density (BMD), a diagnostic parameter for osteoporosis and a clinical predictor
of fracture, is a polygenic trait with high heritability. To identify genetic variants that influence …
of fracture, is a polygenic trait with high heritability. To identify genetic variants that influence …