To ensure tissue homeostasis the brain needs to be protected from blood-derived
fluctuations or pathogens that could affect its function. Therefore, the brain capillaries …

Given the strong trend to implement zebrafish (Danio rerio) embryos as translational model
not only in ecotoxicological, but also toxicological testing strategies, there is an increasing …

Background Increasing use of zebrafish in drug discovery and mechanistic toxicology
demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP …

Chapter 3 in toxicology of fishes addresses the occurrence, regulation, and catalytic
activities of biotransformation systems in fish and concludes with a focus on three model …

Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs),
commonly occur as complex mixtures in the environment. Recent studies using the zebrafish …

This study examined the accumulation and metabolism of a number of drugs and commonly
used probes for human cytochrome P450s (CYPs) in zebrafish larvae under conditions …

The zebrafish (Danio rerio) has been increasingly explored in pharmaceutical research as a
promising alternative model for toxicological screens. This necessitates a thorough …

Over the last 2 decades, the zebrafish (Danio rerio) has emerged as a stellar model for
unraveling molecular signaling events mediated by the aryl hydrocarbon receptor (AHR), an …

We conducted the ecological risk assessment in an urban stream by using multiple-level
approaches ranging from community level, chemical analyses in water and sediments …

Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic
hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor …