Animal Disease Models and Patient-iPS-Cell-Derived In Vitro Disease Models for Cardiovascular Biology—How Close to Disease?

N Kawaguchi, T Nakanishi - Biology, 2023 - mdpi.com
Simple Summary Currently, rodents and pigs are the primary disease models used in
cardiovascular research. Generally, larger animals that are more closely related to humans …

[HTML][HTML] Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?

A Grzeczka, S Graczyk, P Kordowitzki - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Resveratrol (RES) is a polyphenol with natural anti-inflammatory and antioxidant properties.
It is found in abundance in plants, ie, grapes and mulberry fruit. In addition, synthetic forms of …

Unveiling shared therapeutic targets and pathological pathways between coronary artery disease and major depressive disorder through bioinformatics analysis

M Hu, R Tan, C Lu, T Zhou, Q Wang, T Liu - Scientific Reports, 2024 - nature.com
Coronary artery disease (CAD) is a predominant cardiovascular condition influenced by risk
factors, with an emphasis on major depressive disorder (MDD). However, the shared …

Transcriptome Analysis of Myocardial Ischemic‐Hypoxic Injury in Rats and Hypoxic H9C2 Cells

N Niu, H Miao, H Ren - ESC Heart Failure, 2024 - Wiley Online Library
Aims This study aimed to address inconsistencies in results between the H9C2 myocardial
hypoxia (MH) cell line and myocardial infarction (MI) rat models used in MI research. We …

Interleukin-22 inhibits cardiac fibrosis by regulating fibroblast metabolic reprogramming in myocardial infarction

F Liu, Y Chen, D Qin, C Qian - Pathology-Research and Practice, 2024 - Elsevier
Cardiac fibrosis, a significant characteristic of cardiovascular diseases, leads to ventricular
remodeling and impaired cardiac function. In this study, we aimed to investigate the role of …

Exploration of the Location of Coronary Artery Ligation in Rats

Y He, TY Fang, YL Yang, JC Zhou, J Zhang… - Available at SSRN … - papers.ssrn.com
Left coronary artery ligation in mice/rat is a commonly used method for creating animal
models of myocardial infarction or ischemia-reperfusion injury. However, due to the fast …