Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are
involved in the transportation of diverse solute ions and small molecules into cells. There are …

Signal transduction and homeostasis are regulated by complex protein interactions in the
intracellular environment. Therefore, the transportation of impermeable macromolecules …

Abstract Vesicular monoamine transporter 2 (VMAT2) belongs to the major facilitator
superfamily (MFS), and mediates cytoplasmic monoamine packaging into presynaptic …

Human vesicular monoamine transporter 2 (VMAT2), a member of the SLC18 family, plays a
crucial role in regulating neurotransmitters in the brain by facilitating their uptake and …

The norepinephrine transporter (NET) plays a pivotal role in recycling norepinephrine (NE)
from the synaptic cleft. However, the structures referring to the conformational heterogeneity …

The vesicular acetylcholine transporter (VAChT) has a pivotal role in packaging and
transporting acetylcholine for exocytotic release, serving as a vital component of cholinergic …

Neurodegenerative diseases (NDs) represent a hallmark of numerous incapacitating and
untreatable conditions, the incidence of which is escalating swiftly, exemplified by …

Advancements in cryo-EM have stimulated a revolution in structural biology. Yet, for
membrane proteins near the cryo-EM size threshold of approximately 40 kDa, including …

Abstract Vesicular monoamine transporter 2 (VMAT2) is crucial for packaging monoamine
neurotransmitters into synaptic vesicles, with their dysregulation linked to schizophrenia …

Dear Editor, Monoamine neurotransmitters include indolamine serotonin (5-HT), the
catecholamine dopamine (DA), epinephrine (EP), norepinephrine (NE), and imidazolamine …