Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …

The development of chronic pain is considered a major complication after surgery. Basic
science research in animal models helps us understand the transition from acute to chronic …

Background Chronic postsurgical pain can severely impair patient health and quality of life.
This systematic review update evaluated the effectiveness of systemic drugs to prevent …

Background Chronic pain can often occur after surgery, substantially impairing patients'
health and quality of life. It is caused by complex mechanisms that are not yet well …

Postoperative nausea and vomiting (PONV) and pain are two of the major concerns for
patients presenting for surgery. The causes of PONV are multifactorial and can largely be …

Optimal dynamic pain relief is a prerequisite for optimizing post-operative recovery and
reducing morbidity and convalescence. Procedure-specific pain management initiative aims …

Background Nitrous oxide is commonly used in general anaesthesia but concerns exist that
it might increase perioperative cardiovascular risk. We aimed to gather evidence to establish …

Objectives: To investigate the influence of an Acute Pain Service (APS) on the incidence of
chronic postsurgical pain (CPSP). CPSP risk factors include acute postoperative pain …

To investigate the role of peripheral neuropathy in the development of neuropathic
postsurgical persistent pain (N-PSPP) after surgery, this French multicentric prospective …

Chronic postsurgical pain affects between 5 and 75% of patients, often with an adverse
impact on quality of life. While the transition of acute to chronic pain is a complex process …