The present review aims to summarize the pharmacological profile of 1, 2, 4-triazole, one of
the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant …

With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

The ability of Candida spp. to form biofilms is crucial for its pathogenicity, and thus, it should
be considered an important virulence factor in vulvovaginal candidiasis (VVC) and recurrent …

Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

Fungal diseases today represent a world-wide problem. Poor hygiene and decreased
immunity are the main reasons behind the manifestation of this disease. After COVID-19, an …

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence
and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity …

Following their extensive use, azole antifungals may enter the environment through the
discharge of domestic, industrial and hospital wastewaters, agricultural runoffs and as …

Currently, the available antifungal agents have significant clinical incompetency in terms of
their clinical efficacy, antifungal spectrum, unfavorable pharmacokinetic profiles, substantial …