Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Accumulating evidence shows that oxidative stress plays an essential role in the
pathogenesis and progression of many diseases. The imbalance between the production of …

The relationship between the age-associated decline in mitochondrial function and its effect
on skeletal muscle physiology and function remain unclear. In the current study, we …

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate
mitophagy and improve muscle health in old animals and in preclinical models of aging …

Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

Abstract Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and
hallmarks of aging are identified as key contributors to aging, but improving/reversing these …

Abstract Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as
causative factors for aging. Older adults (OAs) have an increased prevalence of elevated …

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …