Infectious diseases caused by antimicrobial-resistant strains have become a serious threat
to global health, with a high social and economic impact. Multi-resistant bacteria exhibit …

The formation of disulfide bonds is critical to the folding of many extracytoplasmic proteins in
all domains of life. With the discovery in the early 1990s that disulfide bond formation is …

Antimicrobial resistance in Gram-negative bacteria is one of the greatest threats to global
health. New antibacterial strategies are urgently needed, and the development of antibiotic …

Anti-virulence strategy is currently considered a promising approach to overcome the global
threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm …

Virulence gene expression can represent a substantial fitness cost to pathogenic bacteria. In
the model entero-pathogen Salmonella Typhimurium (S. Tm), such cost favors emergence of …

Antibiotic resistance has emerged as a serious threat to global public health in recent years.
Lack of novel antimicrobials, especially new classes of compounds, further aggravates the …

The global threat of antibiotic resistance is steadily growing. Antibiotic resistance may
involve any class of antibiotic, including second-and third-line agents that have been …

While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria
meningitidis, the former has become resistant to commonly available over-the-counter …

Gram-negative bacteria are uniquely equipped to defeat antibiotics. Their outermost layer,
the cell envelope, is a natural permeability barrier that contains an array of resistance …

The bacterial proteins of the Dsb family catalyze the formation of disulfide bridges between
cysteine residues that stabilize protein structures and ensure their proper functioning. Here …