Abstract c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however,
emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK …

Fibroblast growth factor (FGF) receptor 4 (FGFR4) belongs to a family of tyrosine kinase
receptor. FGFR4 is highly activated in certain types of cancer and its activation is closely …

Intrinsic and acquired anti-HER2 resistance remains a major hurdle for treating HER2-
positive breast cancer. Using genome-wide CRISPR/Cas9 screening in vitro and in vivo, we …

The fibroblast growth factor receptor (FGFR) signaling pathway has long been known to
cancer researchers because of its role in cell survival, proliferation, migration, and …

Lung cancer is a common malignancy worldwide, with high morbidity and mortality. Signal
transducer and activator of transcription 3 (STAT3) is an important transcription factor that …

Cancer is characterized by diverse genetic alterations in both germline and somatic
genomes that disrupt normal biology and provide a selective advantage to cells during …

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that poses
threats to the public. M. tuberculosis survives in macrophages by escaping from immune …

Tuberculosis, caused by Mycobacterium tuberculosis, engenders an onerous burden on
public hygiene. Congenital and adaptive immunity in the human body act as robust …

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell
survival and increased immune evasion in breast cancer (BCa). Current in vitro models do …

Recent insights into the molecular and cellular mechanisms underlying cancer development
have revealed the tumor microenvironment (TME) immune cells to functionally affect the …