The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

The most common genetic risk factors for Parkinson's disease (PD) are a set of
heterozygous mutant (MT) alleles of the GBA1 gene that encodes β-glucocerebrosidase …

Neuroinflammation is a pathological change that is involved in the progression of
Parkinson's disease. Dysfunction of chaperone-mediated autophagy (CMA) has …

Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …

It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in
1817. The disease is the second most common neurodegenerative disease characterized …

Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often
causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded …

Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including
the unfolded protein response (UPR) and autophagy, and induces programmed cell death …

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and it
is characterized by the selective loss of dopaminergic (DA) neurons in the substantia nigra …