Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments

MA Elafros, H Andersen, DL Bennett… - The Lancet …, 2022 - thelancet.com
Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention

D Selvarajah, D Kar, K Khunti, MJ Davies… - The lancet Diabetes & …, 2019 - thelancet.com
Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2
diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain …

Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment

J Zhu, Z Hu, Y Luo, Y Liu, W Luo, X Du, Z Luo… - Frontiers in …, 2024 - frontiersin.org
Diabetic peripheral neuropathy (DPN) refers to the development of peripheral nerve
dysfunction in patients with diabetes when other causes are excluded. Diabetic distal …

Neurological consequences of obesity

PD O'Brien, LM Hinder, BC Callaghan… - The Lancet …, 2017 - thelancet.com
The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …

Diagnosis and treatment of painful diabetic peripheral neuropathy

R Pop-Busui, L Ang, AJM Boulton, EL Feldman… - 2022 - Am Diabetes Assoc
Diabetic neuropathies are the most common chronic complications of diabetes, with an
estimated lifetime prevalence exceeding 50% in people with diabetes. Among various forms …

Emerging biomarkers, tools, and treatments for diabetic polyneuropathy

GJ Bönhof, C Herder, A Strom, N Papanas… - Endocrine …, 2019 - academic.oup.com
Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

[HTML][HTML] Diabetic neuropathy

EL Feldman, BC Callaghan, R Pop-Busui… - Nature reviews Disease …, 2019 - nature.com
The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …

Risk factors for incident diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years: ADDITION-Denmark

ST Andersen, DR Witte, EM Dalsgaard… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE To study incident diabetic polyneuropathy (DPN) prospectively during the first
13 years after a screening-based diagnosis of type 2 diabetes and determine the associated …

Metabolic syndrome and peripheral neuropathy

M Kazamel, AM Stino, AG Smith - Muscle & Nerve, 2021 - Wiley Online Library
Diabetic peripheral neuropathy and metabolic syndrome (MetS) are both global health
challenges with well‐established diagnostic criteria and significant impacts on quality of life …

Diabetes and obesity are the main metabolic drivers of peripheral neuropathy

BC Callaghan, LL Gao, Y Li, X Zhou… - Annals of clinical …, 2018 - Wiley Online Library
Objective To determine the associations between individual metabolic syndrome (MetS)
components and peripheral neuropathy in a large population‐based cohort from Pinggu …