Protein toxicity can be defined as all the pathological changes that ensue from
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …

Currently, neurodegenerative diseases are a major cause of disability around the world.
Parkinson's disease (PD) is the second-leading cause of neurodegenerative disorder after …

Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites,
which are pathological hallmarks of Parkinson's disease (PD). The contribution of αSyn to …

Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-
encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to …

Alpha-synuclein is a component of Lewy bodies, the pathological hallmark of Parkinson's
disease (PD), and is also mutated in familial PD. Here, by extensively analyzing PD patient …

Oxidative stress plays an essential role in the development of Parkinson's disease (PD). 8-
oxo-7, 8-dihydroguanine (8-oxodG, oxidized guanine) is the most abundant oxidative stress …

Mitochondrial and cytosolic proteostasis are of central relevance for cellular stress
resistance and organismal health. Recently, a number of individual cellular programs were …

Parkinson's disease (PD) is a severe neurodegenerative disorder caused by the progressive
loss of dopaminergic neurons in the substantia nigra and affects millions of people …

Abstract Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been
implicated in the pathology of Parkinson's disease (PD). Although studies suggest that αSyn …

Parkinson's disease, a progressive neurodegenerative disorder predominantly affecting
elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway …