Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to
proinsulin misfolding and its retention in endoplasmic reticulum (ER). This results in …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or
impairing β cell function. Understanding the genetic basis of rare diabetes subtypes …

Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-
transcriptionally they are heavily modified to improve their function, folding and stability …

Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of
insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which …