To fix or not to fix: maintenance of chromosome ends versus repair of DNA double-strand breaks
E Casari, M Gnugnoli, C Rinaldi, P Pizzul, CV Colombo… - Cells, 2022 - mdpi.com
Early work by Muller and McClintock discovered that the physical ends of linear
chromosomes, named telomeres, possess an inherent ability to escape unwarranted …
chromosomes, named telomeres, possess an inherent ability to escape unwarranted …
The regulation of the DNA damage response at telomeres: focus on kinases
M Galli, C Frigerio, MP Longhese… - Biochemical Society …, 2021 - portlandpress.com
The natural ends of linear chromosomes resemble those of accidental double-strand breaks
(DSBs). DSBs induce a multifaceted cellular response that promotes the repair of lesions …
(DSBs). DSBs induce a multifaceted cellular response that promotes the repair of lesions …
Modified chromosome structure caused by phosphomimetic H2A modulates the DNA damage response by increasing chromatin mobility in yeast
F García Fernández, B Lemos, Y Khalil… - Journal of cell …, 2021 - journals.biologists.com
In budding yeast and mammals, double-strand breaks (DSBs) trigger global chromatin
mobility together with rapid phosphorylation of histone H2A over an extensive region of the …
mobility together with rapid phosphorylation of histone H2A over an extensive region of the …
[HTML][HTML] Exo1 cooperates with Tel1/ATM in promoting recombination events at DNA replication forks
M Galli, C Frigerio, CV Colombo, E Casari… - Iscience, 2024 - cell.com
Tel1/ataxia telangiectasia mutated (ATM) kinase plays multiple functions in response to DNA
damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In …
damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In …
Telomere instability initiates and then boosts carcinogenesis by the butterfly effect
C Herate, L Sabatier - Current Opinion in Genetics & Development, 2020 - Elsevier
Telomeres are composed of DNA repeat sequences at the ends of chromosomes that recruit
a multitude of proteins to form a complex loop structure at each extremity. The integrity of this …
a multitude of proteins to form a complex loop structure at each extremity. The integrity of this …
Origin, Regulation, and Fitness Effect of Chromosomal Rearrangements in the Yeast Saccharomyces cerevisiae
XX Tang, XP Wen, L Qi, Y Sui, YX Zhu… - International Journal of …, 2021 - mdpi.com
Chromosomal rearrangements comprise unbalanced structural variations resulting in gain
or loss of DNA copy numbers, as well as balanced events including translocation and …
or loss of DNA copy numbers, as well as balanced events including translocation and …
Chromosome structure due to phospho-mimetic H2A modulates DDR through increased chromatin mobility
FG Fernandez, B Lemos, Y Khalil, R Batrin, JE Haber… - bioRxiv, 2020 - biorxiv.org
In budding yeast and mammals, double strand breaks trigger global chromatin mobility
together with the rapid phosphorylation of the histone H2A over an extensive region of the …
together with the rapid phosphorylation of the histone H2A over an extensive region of the …