[HTML][HTML] The translational challenge in Chagas disease drug development
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …
Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1
A Mukherjee, Z Hossain, E Erben, S Ma… - Nature …, 2023 - nature.com
Abstract Replication Protein A (RPA) is a broadly conserved complex comprised of the
RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during …
RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during …
Metacyclogenesis as the Starting Point of Chagas Disease
AZL Ferreira, CN de Araújo, ICC Cardoso… - International Journal of …, 2023 - mdpi.com
Chagas disease is a neglected infectious disease caused by the protozoan Trypanosoma
cruzi, primarily transmitted by triatomine vectors, and it threatens approximately seventy-five …
cruzi, primarily transmitted by triatomine vectors, and it threatens approximately seventy-five …
H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host …
JN Rosón, MO Vitarelli, HM Costa-Silva… - PLoS …, 2022 - journals.plos.org
Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …
Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2
M Marek, E Ramos-Morales, GFA Picchi-Constante… - Cell Reports, 2021 - cell.com
Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and
antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries …
antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries …
[HTML][HTML] Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems
In trypanosomatids, etiological agents of devastating diseases, replication is robust and
finely controlled to maintain genome stability and function in stressful environments …
finely controlled to maintain genome stability and function in stressful environments …
Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment
One of the most important mechanisms for repairing double-strand breaks (DSBs) in model
eukaryotes is homologous recombination (HR). Although the genes involved in HR have …
eukaryotes is homologous recombination (HR). Although the genes involved in HR have …
A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis
Background Telomeres are chromosome end structures important in the maintenance of
genome homeostasis. They are replenished by the action of telomerase and associated …
genome homeostasis. They are replenished by the action of telomerase and associated …
ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten
genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a …
genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a …
DNA Topoisomerase 3α Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi
HM Costa-Silva, BC Resende, ACS Umaki… - Frontiers in Cell and …, 2021 - frontiersin.org
DNA topoisomerases are enzymes that modulate DNA topology. Among them,
topoisomerase 3α is engaged in genomic maintenance acting in DNA replication …
topoisomerase 3α is engaged in genomic maintenance acting in DNA replication …