Tracking placental development in health and disease

JD Aplin, JE Myers, K Timms… - Nature Reviews …, 2020 - nature.com
Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Biological functions and current advances in isolation and detection strategies for exosome nanovesicles

K Boriachek, MN Islam, A Möller, C Salomon… - Small, 2018 - Wiley Online Library
Abstract Exosomes are nanoscale (≈ 30–150 nm) extracellular vesicles of endocytic origin
that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific …

Extracellular vesicles and their emerging roles as cellular messengers in endocrinology: an endocrine society scientific statement

C Salomon, S Das, U Erdbrügger, R Kalluri… - Endocrine …, 2022 - academic.oup.com
During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …

Exosomes and nanoengineering: a match made for precision therapeutics

PHL Tran, D Xiang, TTD Tran, W Yin… - Advanced …, 2020 - Wiley Online Library
Targeted exosomal delivery systems for precision nanomedicine attract wide interest across
areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes …

Extracellular vesicles in human reproduction in health and disease

C Simon, DW Greening, D Bolumar… - Endocrine …, 2018 - academic.oup.com
Extensive evidence suggests that the release of membrane-enclosed compartments, more
commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Exosomes: potential disease biomarkers and new therapeutic targets

MI Mosquera-Heredia, LC Morales, OM Vidal… - Biomedicines, 2021 - mdpi.com
Exosomes are extracellular vesicles released by cells, both constitutively and after cell
activation, and are present in different types of biological fluid. Exosomes are involved in the …

Advanced liquid biopsy technologies for circulating biomarker detection

N Soda, BHA Rehm, P Sonar, NT Nguyen… - Journal of Materials …, 2019 - pubs.rsc.org
Liquid biopsy is a new diagnostic concept that provides important information for monitoring
and identifying tumor genomes in body fluid samples. Detection of tumor origin …

Exosomes as biomarkers for female reproductive diseases diagnosis and therapy

S Esfandyari, H Elkafas, RM Chugh, H Park… - International journal of …, 2021 - mdpi.com
Cell–cell communication is an essential mechanism for the maintenance and development
of various organs, including the female reproductive system. Today, it is well-known that the …

The exosome: a review of current therapeutic roles and capabilities in human reproduction

M Dimik, P Abeysinghe, J Logan, M Mitchell - Drug Delivery and …, 2023 - Springer
Abstract Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …