RING domain E3 ubiquitin ligases
RJ Deshaies, CAP Joazeiro - Annual review of biochemistry, 2009 - annualreviews.org
E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human
Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …
The galvanization of biology: a growing appreciation for the roles of zinc
Zinc ions are key structural components of a large number of proteins. The binding of zinc
stabilizes the folded conformations of domains so that they may facilitate interactions …
stabilizes the folded conformations of domains so that they may facilitate interactions …
Arsenic trioxide controls the fate of the PML-RARα oncoprotein by directly binding PML
Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide
interest because it shows substantial anticancer activity in patients with acute promyelocytic …
interest because it shows substantial anticancer activity in patients with acute promyelocytic …
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
DE Jensen, M Proctor, ST Marquis, HP Gardner, SI Ha… - Oncogene, 1998 - nature.com
We have identified a novel protein, BAP1, which binds to the RING finger domain of the
Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized …
Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized …
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
S Fang, JP Jensen, RL Ludwig, KH Vousden… - Journal of Biological …, 2000 - ASBMB
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …
TRIM/RBCC, a novel class of 'single protein RING finger'E3 ubiquitin ligases
G Meroni, G Diez‐Roux - Bioessays, 2005 - Wiley Online Library
The TRIM/RBCC proteins are defined by the presence of the tripartite motif composed of a
RING domain, one or two B‐box motifs and a coiled‐coil region. These proteins are involved …
RING domain, one or two B‐box motifs and a coiled‐coil region. These proteins are involved …
TRIM family proteins: retroviral restriction and antiviral defence
Members of the tripartite motif (TRIM) protein family are involved in various cellular
processes, including cell proliferation, differentiation, development, oncogenesis and …
processes, including cell proliferation, differentiation, development, oncogenesis and …
Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
JR Friedman, WJ Fredericks, DE Jensen… - Genes & …, 1996 - genesdev.cshlp.org
The KRAB repression domain is one of the most widely distributed transcriptional effector
domains yet identified, but its mechanism of repression is unknown. We have cloned a …
domains yet identified, but its mechanism of repression is unknown. We have cloned a …