This review describes the diffusion model for light transport in tissues and the medical
applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue …

Fluorescence sampling of cellular function is widely used in all aspects of biology, allowing
the visualization of cellular and sub-cellular biological processes with spatial resolutions in …

Time-correlated single photon counting (TCSPC) is based on the detection of single photons
of a periodic light signal, measurement of the detection time of the photons, and the build-up …

Emerging fluorescence and bioluminescence tomography approaches have several
common, yet several distinct features from established emission tomographies of PET and …

This book reflects the remarkable advances in time-resolved fluorescence techniques and
their role in a wide range of biological and clinical applications. Fluorescence lifetime …

Diffuse optical tomography is emerging as a viable new biomedical imaging modality. Using
visible and near-infrared light this technique can probe the absorption and scattering …

We describe the application of a time domain diffuse fluorescence tomography system for
whole body small animal imaging. The key features of the system are the use of point …

In this paper, we propose a dual-excitation-mode methodology for three-dimensional (3D)
fluorescence molecular tomography (FMT). For this modality, an effective reconstruction …

A general linear model for time domain (TD) fluorescence tomography is presented that
allows a lifetime-based analysis of the entire temporal fluorescence response from a turbid …

Local molecular and physiological processes can be imaged in vivo through perturbations in
the fluorescence lifetime (FLT) of optical imaging agents. In addition to providing functional …