Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of
medicines that directly reprogramme the central dogma of biology to prevent and treat …

MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

The universal increase in the number of patients with nonhealing skin wounds imposes a
huge social and economic burden on the patients and healthcare systems. Although, the …

Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …

Transfection is a modern and powerful method used to insert foreign nucleic acids into
eukaryotic cells. The ability to modify host cells' genetic content enables the broad …

Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease …

Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …