Epigenetic modifications of histones in cancer
Z Zhao, A Shilatifard - Genome biology, 2019 - Springer
The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …
development and disease pathogenesis including human cancers. In this review, we will …
The chemical biology of reversible lysine post-translational modifications
Lysine (Lys) residues in proteins undergo a wide range of reversible post-translational
modifications (PTMs), which can regulate enzyme activities, chromatin structure, protein …
modifications (PTMs), which can regulate enzyme activities, chromatin structure, protein …
Mechanism of cross-talk between H2B ubiquitination and H3 methylation by Dot1L
Methylation of histone H3 K79 by Dot1L is a hallmark of actively transcribed genes that
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
Structural basis of salicylic acid perception by Arabidopsis NPR proteins
Salicylic acid (SA) is a plant hormone that is critical for resistance to pathogens,–. The NPR
proteins have previously been identified as SA receptors,,,,,–, although how they perceive …
proteins have previously been identified as SA receptors,,,,,–, although how they perceive …
Structural basis of nucleosome recognition and modification by MLL methyltransferases
H Xue, T Yao, M Cao, G Zhu, Y Li, G Yuan, Y Chen… - Nature, 2019 - nature.com
Methyltransferases of the mixed-lineage leukaemia (MLL) family—which include MLL1,
MLL2, MLL3, MLL4, SET1A and SET1B—implement methylation of histone H3 on lysine 4 …
MLL2, MLL3, MLL4, SET1A and SET1B—implement methylation of histone H3 on lysine 4 …
Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation
W Zhao, Y Xu, Y Wang, D Gao, J King, Y Xu… - Scientific reports, 2021 - nature.com
Epigenome editing methods enable the precise manipulation of epigenetic modifications,
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …
Histone modifications and their regulatory roles in plant development and environmental memory
T Zhao, Z Zhan, D Jiang - Journal of genetics and genomics, 2019 - Elsevier
Plants grow in dynamic environments where they receive diverse environmental signals.
Swift and precise control of gene expression is essential for plants to align their …
Swift and precise control of gene expression is essential for plants to align their …
Structural basis of H2B ubiquitination-dependent H3K4 methylation by COMPASS
The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
EJ Worden, X Zhang, C Wolberger - Elife, 2020 - elifesciences.org
Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …
The benefits of cotranslational assembly: a structural perspective
The faithful assembly of protein complexes in space and time is a hallmark of cellular
homeostasis. Complex assembly might be seeded already during translation, if interacting …
homeostasis. Complex assembly might be seeded already during translation, if interacting …