According to the β-amyloid (Aβ) hypothesis of Alzheimer's disease (AD), brain Aβ
accumulation is the primary cascade event leading to cognitive deficit and dementia …

A biomedical hypothesis is a theoretical assumption amenable to being tested in a
randomized clinical trial. The main hypotheses in neurodegenerative disorders are based …

Background: In amyloid-positive individuals at risk for Alzheimer's disease (AD), high
soluble 42-amino acid amyloid-β (Aβ42) levels are associated with normal cognition. It is …

Proteins only function in their normal state (soluble monomers) and cease to function when
transformed intocross-βfibers (insolubleamyloids). Thisisabiophysical inevitability. What is …

Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

The toxic proteinopathy paradigm has defined neurodegenerative disorders for over a
century. This gain-of-function (GOF) framework posited that proteins become toxic when …

These facts argue against the gain-of-function synucleinopathy hypothesis, which proposes
that Lewy pathology causes Parkinson's disease:(1) most brains from people without …

The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological
complications in patients, known as long COVID, have renewed the interest in the …

The clinicopathologic model that defines neurodegenerative disorders has remained
unchanged for over a century. According to it, clinical manifestations are defined and …

The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological
complications in patients, known as long COVID, have renewed interest in the correlation …