Caffeic acid and its derivatives: antimicrobial drugs toward microbial pathogens

F Khan, NI Bamunuarachchi… - Journal of agricultural …, 2021 - ACS Publications
Caffeic acid is a plant-derived compound that is classified as hydroxycinnamic acid which
contains both phenolic and acrylic functional groups. Caffeic acid has been greatly …

A review of the health protective effects of phenolic acids against a range of severe pathologic conditions (including coronavirus-based infections)

S Kiokias, V Oreopoulou - Molecules, 2021 - mdpi.com
Phenolic acids comprise a class of phytochemical compounds that can be extracted from
various plant sources and are well known for their antioxidant and anti-inflammatory …

Polyphenol and tannin nutraceuticals and their metabolites: How the human gut microbiota influences their properties

M Fabbrini, F D'Amico, M Barone, G Conti, M Mengoli… - Biomolecules, 2022 - mdpi.com
Nutraceuticals have been receiving increasing attention in the last few years due to their
potential role as adjuvants against non-communicable chronic diseases (cardiovascular …

Fosfomycin as partner drug for systemic infection management. A systematic review of its synergistic properties from in vitro and in vivo studies

RM Antonello, L Principe, AE Maraolo, V Viaggi, R Pol… - Antibiotics, 2020 - mdpi.com
Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In
patients with systemic involvement, intravenous fosfomycin is usually administered as a …

Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy

S Maity, M Kinra, M Nampoothiri, D Arora, KSR Pai… - Chemical Papers, 2022 - Springer
Increased effectiveness and decreasing toxicity are prime objectives in drug research.
Overwhelming evidence suggests the use of appropriate combination therapy for the better …

Investigating the synergistic antibacterial effects of chlorogenic and p-coumaric acids on Shigella dysenteriae

Y Liu, L Guan, D Yang, H Luo, H Zhang - Food chemistry, 2025 - Elsevier
Chlorogenic acid (CGA) is a well-known plant secondary metabolite exhibiting multiple
physiological functions. The present study focused on screening for synergistic antibacterial …

Optimisation of polyphenols extraction from wild bilberry leaves—Antimicrobial properties and stability studies

AM Brezoiu, M Deaconu, RA Mitran, AM Prelipcean… - Molecules, 2023 - mdpi.com
Polyphenolic extracts from natural sources have received great interest due to their
beneficial properties for human health. A method to reduce their variability is to use the …

An integrated computational and experimental approach to identifying inhibitors for SARS-CoV-2 3CL protease

T Zhai, F Zhang, S Haider, D Kraut… - Frontiers in molecular …, 2021 - frontiersin.org
The newly evolved SARS-CoV-2 has caused the COVID-19 pandemic, and the SARS-CoV-
2 main protease 3CLpro is essential for the rapid replication of the virus. Inhibiting this …

Synergistic effect of phenylpropanoids and flavonoids with antibiotics against Gram-positive and Gram-negative bacterial strains

A Kincses, TSA Ghazal, J Hohmann - Pharmaceutical Biology, 2024 - Taylor & Francis
Context The increase in bacterial resistance to currently available medications, which
increases mortality rates, treatment costs is a global problem, and highlights the need for …

Investigation of Potential Drug Targets Involved in Inflammation Contributing to Alzheimer's Disease Progression

C Sharo, T Zhai, Z Huang - Pharmaceuticals, 2024 - mdpi.com
Alzheimer's disease has become a major public health issue. While extensive research has
been conducted in the last few decades, few drugs have been approved by the FDA to treat …