Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus
increasing blood volume and pressure. Excessive production of aldosterone results in high …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

Primary aldosteronism is the most common and curable form of secondary arterial
hypertension. We performed whole-exome sequencing in patients with early-onset primary …

The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome
P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the …

Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations
in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma …

Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …

Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that
constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of …

We recently demonstrated that a recurrent gain-of-function mutation in a T-type calcium
channel, CACNA1HM1549V, causes a novel Mendelian disorder featuring early-onset …

The antifungal agent ketoconazole is often used to suppress cortisol production in patients
with Cushing's syndrome (CS). However, ketoconazole has serious side effects and is …

Triple A syndrome is caused by mutations in AAAS encoding the protein ALADIN. We
investigated the role of ALADIN in the human adrenocortical cell line NCI-H295R1 by either …