All mucosal surfaces must deal with the challenge of exposure to the outside world. The
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …

The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its
molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis …

Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic
kidney disease (CKD), the mechanisms determining the transition from acute to irreversible …

Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …

Cancer stem cells (CSC) are purported to initiate and maintain tumor growth. Deregulation
of normal stem cell signaling may lead to the generation of CSCs; however, the molecular …

Increased cancer stem cell content during development of resistance to tamoxifen in breast
cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling …

After acute kidney injury (AKI), surviving cells within the nephron proliferate and repair. We
identify Sox9 as an acute epithelial stress response in renal regeneration. Translational …

SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box
transcription factor, plays critical roles during embryogenesis and its activity is required for …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …