Obesity caused by genetic and environmental factors can lead to compromised skeletal
muscle function. Time-restricted feeding (TRF) has been shown to prevent muscle function …

Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian
rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of …

In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight
and leg muscles are the major voluntary locomotory organs. They share several …

Nuclear lamins, a type V intermediate filament, are crucial components of the nuclear
envelope's inner layer, maintaining nuclear integrity and mediating interactions between the …

Lamin A/C (LMNA) is an important component of nuclear lamina. Mutations cause
arrhythmia, heart failure, and sudden cardiac death. While LMNA-associated …

Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have
been shown to modulate transcriptional control by RNA polymerase II. We found that …

Mutations in the human LMNA gene cause a collection of diseases called laminopathies,
which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes …

Abstract Lamin A/C gene (LMNA) mutations contribute to severe striated muscle
laminopathies, affecting cardiac and skeletal muscles, with limited treatment options. In this …

Mutations in the LMNA gene cause diseases called laminopathies. LMNA encodes lamins A
and C, intermediate filaments with multiple roles at the nuclear envelope. LMNA mutations …

The epidermal growth factor receptor (EGFR) is highly expressed in many non-small cell
lung cancers (NSCLC), necessitating the use of EGFR-tyrosine kinase inhibitors (TKIs) as …