Glaucoma is the leading cause of irreversible blindness worldwide. Although most
glaucoma patients are elderly, congenital glaucoma and glaucomas of childhood are also …

During vertebrate embryonic development, a population of dorsal neural tube-derived stem
cells, termed the neural crest (NC), undergo a series of morphogenetic changes and …

Cytochrome P450 1B1 (CYP1B1) is a major E2 hydroxylase involved in the metabolism of
potential carcinogens. CYP1B1 expression has been reported to be higher in tumors …

Glaucoma is the leading cause of irreversible blindness worldwide. The primary cause of
glaucoma is not known, but several risk factors have been identified, including elevated …

PURPOSE: To screen primary congenital glaucoma patients in the United States for
sequence variants within the CYP1B1, LTBP2, and MYOC genes using Sanger and whole …

Purpose Primary congenital glaucoma (PCG) is a severe form of glaucoma that presents
early in life. PCG is a clinical and genetic entity that is distinct from juvenile forms of …

The objective of this study was to investigate the distribution of mutations in the Cytochrome
P450 1B1 gene (CYP1B1) in patients with primary congenital glaucoma (PCG) among …

Primary congenital glaucoma (PCG) is a genetically heterogeneous autosomal recessive
disorder, which is an important cause of blindness in childhood. The first known gene …

Primary congenital glaucoma (PCG) is one of the primary causes of blindness in children
and is characterized by congenital trabecular meshwork and anterior chamber angle …

CYP1B1 has been implicated in primary congenital glaucoma with autosomal recessive
mode of inheritance. Mutations in CYP1B1 have also been reported in primary open angle …