The neural circuits underlying general anesthesia and sleep
General anesthesia is characterized by loss of consciousness, amnesia, analgesia, and
immobility. Important molecular targets of general anesthetics have been identified, but the …
immobility. Important molecular targets of general anesthetics have been identified, but the …
General anesthesia, sleep, and coma
General Anesthesia, Sleep, and Coma | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate model
Loss of consciousness is associated with the disruption of long-range thalamocortical and
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …
Consciousness and anesthesia
When we are anesthetized, we expect consciousness to vanish. But does it always?
Although anesthesia undoubtedly induces unresponsiveness and amnesia, the extent to …
Although anesthesia undoubtedly induces unresponsiveness and amnesia, the extent to …
In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape
To understand how pharmacological interventions can exert their powerful effects on brain
function, we need to understand how they engage the brain's rich neurotransmitter …
function, we need to understand how they engage the brain's rich neurotransmitter …
Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …
understanding of the mechanisms of action of general anesthetics, coincident with progress …
Thalamic dual control of sleep and wakefulness
TC Gent, M Bandarabadi, CG Herrera… - Nature …, 2018 - nature.com
Abstract Slow waves (0.5–4 Hz) predominate in the cortical electroencephalogram during
non-rapid eye movement (NREM) sleep in mammals. They reflect the synchronization of …
non-rapid eye movement (NREM) sleep in mammals. They reflect the synchronization of …
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
NP Franks - Nature Reviews Neuroscience, 2008 - nature.com
The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …
The neural correlates of consciousness: an update
This review examines recent advances in the study of brain correlates of consciousness.
First, we briefly discuss some useful distinctions between consciousness and other brain …
First, we briefly discuss some useful distinctions between consciousness and other brain …
Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia
Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as
dextroamphetamine and methylphenidate are effective for increasing arousal and inducing …
dextroamphetamine and methylphenidate are effective for increasing arousal and inducing …