Gliomas are molecularly heterogeneous brain tumors responsible for the most years of life
lost by any cancer. High-grade gliomas have a poor prognosis and despite multimodal …

Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse
gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a …

Glioblastoma (GBM) is one of the most aggressive malignant tumors of the brain. We
queried PubMed for articles about molecular predictor markers in GBM. This scoping review …

Purpose: Although fewer than 5% of high-grade gliomas (HGG) are BRAF-V600E mutated,
these tumors are notable as BRAF-targeted therapy shows efficacy for some populations …

As the mitogen-activated protein kinase (MAPK) signalling pathway is activated in many
paediatric cancers, it is an important therapeutic target. Currently, a range of targeted MAPK …

BRAFV600E represents the most common BRAF mutation in all human cancers. Among
central nervous system (CNS) tumors, BRAFV600E is mostly found in pediatric low-grade …

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite
an established standard of care including surgical resection, radiation therapy, and …

Molecular profiling has transformed the diagnostic workflow of CNS tumors during the last
years. The latest WHO classification of CNS tumors (5th edition), published in 2021, pushed …