γδ T cells: unexpected regulators of cancer development and progression

C Fleming, S Morrissey, Y Cai, J Yan - Trends in cancer, 2017 - cell.com
Accumulating evidence suggests a role for gamma delta (γδ) T cells as unexpected drivers
of tumor development and progression. These protumoral γδ T cells are abundant in the …

[HTML][HTML] IL-17 in pancreatic disease: pathogenesis and pharmacotherapy

F Hu, F Guo, Y Zhu, Q Zhou, T Li, H Xiang… - American journal of …, 2020 - ncbi.nlm.nih.gov
Increasing evidence highlights the role of the interleukin (IL)-17 family in pancreatic
diseases. IL-17A induces acinar cell injury directly, recruits neutrophils, and cooperates with …

Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes

Y Zhao, Y Li, J Wang, RK Manthari, J Wang - Archives of toxicology, 2018 - Springer
Previous studies have reported that excessive fluoride exposure induced liver damage.
However, the underlying mechanism of fluoride-induced hepatic toxicity is still unclear …

Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma

IA Khan, N Singh, D Gunjan, S Gopi, NR Dash, S Gupta… - Immunogenetics, 2023 - Springer
Abstract T-helper 17 (Th17) cells are a subset of CD4+ helper T cells that produce
interleukin 17 (IL-17) and play a crucial role in the pathogenesis of inflammatory and …

Interleukin-17 activates and synergizes with the notch signaling pathway in the progression of pancreatic ductal adenocarcinoma

X Wang, H Chen, R Jiang, X Hong, J Peng, W Chen… - Cancer Letters, 2021 - Elsevier
Abstract Interleukin (IL)-17 is a prominent cytokine that promotes pancreatic intraepithelial
neoplasia (PanIN) and pancreatic ductal adenocarcinoma (PDAC) and is associated with …

Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer

Z Chen, S Qiao, L Yang, M Sun, B Li, A Lu… - International Journal of …, 2023 - mdpi.com
The members of the cytokine interleukin 17 (IL-17) family, along with their receptors (IL-
17R), are vital players in a range of inflammatory diseases and cancer. Although generally …

Inflammation, tumoral markers and interleukin-17,-10, and-6 profiles in pancreatic adenocarcinoma and chronic pancreatitis

A Tanţău, DC Leucuţa, M Tanţău, E Boţan… - Digestive Diseases and …, 2021 - Springer
Background Interleukin profiles can be used as biochemical markers regarding the early
diagnosis of pancreatic cancer. Aims To assess CRP, CA 19-9, CEA levels, and interleukin …

The increased IL-17-producing γδT cells promote tumor cell proliferation and migration in neuroblastoma

H Zhang, W Chai, W Yang, W Han, W Mou, Y Xi… - Clinical …, 2020 - Elsevier
Neuroblastoma (NB) is the most common solid extracranial malignancy in children with a
considerable chance of metastatic progression. Prevalent evidence supports the anti-tumor …

The role of interleukin 17 in cancer: a systematic review

E Begagic, S Vranic, A Sominanda - Carcinogenesis, 2025 - academic.oup.com
Abstract Interleukin 17 (IL17) is a cytokine involved in immune regulation and has been
increasingly recognized for its role in cancer progression. This systematic review aims to …

Pathogenic Role of an IL-23/γδT17/Neutrophil Axis in Coxsackievirus B3–Induced Pancreatitis

K Yan, J Yang, Q Qian, D Xu, H Liu, L Wei… - The Journal of …, 2019 - journals.aai.org
Coxsackievirus B is a common cause of viral myocarditis and pancreatitis. IL-17A is
intensively involved in the pathogenesis of viral myocarditis. Whether IL-17A plays a role in …