AS Goustin, EB Leof, GD Shipley, HL Moses - Cancer research, 1986 - AACR
Summary and Conclusions Growth factors, defined as polypeptides that stimulate cell proliferation, are major growth-regulatory molecules for cells in culture and probably also for …
Drug sensitivity and resistance are conventionally quantified by IC50 or E max values, but these metrics are highly sensitive to the number of divisions taking place over the course of …
J Downward, Y Yarden, E Mayes, G Scrace, N Totty… - Nature, 1984 - nature.com
Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian …
MH Kraus, W Issing, T Miki… - Proceedings of the …, 1989 - National Acad Sciences
A related DNA fragment distinct from the epidermal growth factor receptor and ERBB2 genes was detected by reduced stringency hybridization of v-erbB to normal genomic human DNA …
AB Roberts, MA Anzano… - Proceedings of the …, 1985 - National Acad Sciences
Type beta transforming growth factor (TGF-beta) is a two-chain polypeptide of 25,000 daltons isolated from many tissues, including bovine kidney, human placenta, and human …
JD Vassalli, D Baccino, D Belin - The Journal of cell biology, 1985 - rupress.org
The secretion of plasminogen activators has been implicated in the controlled extracellular proteolysis that accompanies cell migration and tissue remodeling. We found that the human …
C Knabbe, ME Lippman, LM Wakefield, KC Flanders… - Cell, 1987 - cell.com
The hormone-dependent human breast cancer cell line MCF-7 secretes transforming growth factor-8 (TGF-p), which can be detected in the culture medium in a biologically active form …
DA Bronzert, P Pantazis… - Proceedings of the …, 1987 - National Acad Sciences
We report that human breast cancer cells secrete a growth factor that is biologically and immunologically similar to platelet-derived growth factor (PDGF). Serum-free medium …
H Marquardt, MW Hunkapiller, LE Hood, GJ Todaro - Science, 1984 - science.org
The complete amino acid sequence of rat transforming growth factor type 1 has been determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is …