The amyloid hypothesis of Alzheimer's disease has long been the predominant theory,
suggesting that Alzheimer's disease is caused by the accumulation of amyloid beta protein …

Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …

Inflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Some
evidence suggests that misfolded protein aggregates found in AD brains may have …

Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …

There is growing evidence that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …

Population-based clinic-pathological studies have established that the most common
pathological substrate of dementia in community-dwelling elderly people is mixed …

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …

Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative
disease with clinical characteristics of memory loss, dementia and cognitive impairment …