Fever and the thermal regulation of immunity: the immune system feels the heat

SS Evans, EA Repasky, DT Fisher - Nature Reviews Immunology, 2015 - nature.com
Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

NR Datta, SG Ordóñez, US Gaipl, MM Paulides… - Cancer treatment …, 2015 - Elsevier
Hyperthermia, one of the oldest forms of cancer treatment involves selective heating of tumor
tissues to temperatures ranging between 39 and 45° C. Recent developments based on the …

[HTML][HTML] Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

DR Ciocca, SK Calderwood - Cell stress & chaperones, 2005 - ncbi.nlm.nih.gov
Heat shock proteins (Hsps) are overexpressed in a wide range of human cancers and are
implicated in tumor cell proliferation, differentiation, invasion, metastasis, death, and …

Local tumour hyperthermia as immunotherapy for metastatic cancer

S Toraya-Brown, S Fiering - International journal of hyperthermia, 2014 - Taylor & Francis
Local tumour hyperthermia for cancer treatment is currently used either for ablation
purposes as an alternative to surgery or less frequently, in combination with chemotherapy …

More than one reason to rethink the use of peptides in vaccine design

AW Purcell, J McCluskey, J Rossjohn - Nature reviews Drug discovery, 2007 - nature.com
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …

DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy

T Yata, Y Takahashi, M Tan, H Nakatsuji, S Ohtsuki… - Biomaterials, 2017 - Elsevier
Success of tumor photothermal immunotherapy requires a system that induces heat stress in
cancer cells and enhances strong anti-tumor immune responses. Here, we designed a …

Hyperthermia adds to chemotherapy

RD Issels - European journal of cancer, 2008 - Elsevier
The hallmarks of hyperthermia and its pleotropic effects are in favour of its combined use
with chemotherapy. Preclinical research reveals that for heat killing and synergistic effects …

Heat shock protein–peptide and HSP-based immunotherapies for the treatment of cancer

M Shevtsov, G Multhoff - Frontiers in immunology, 2016 - frontiersin.org
Intracellular residing heat shock proteins (HSPs) with a molecular weight of approximately
70 and 90 kDa function as molecular chaperones that assist folding/unfolding and transport …

Integrating hyperthermia into modern radiation oncology: what evidence is necessary?

JC Peeken, P Vaupel, SE Combs - Frontiers in oncology, 2017 - frontiersin.org
Hyperthermia (HT) is one of the hot topics that have been discussed over decades.
However, it never made its way into primetime. The basic biological rationale of heat to …

[HTML][HTML] Extracellular heat shock proteins in cell signaling

SK Calderwood, SS Mambula, PJ Gray Jr, JR Theriault - FEBS letters, 2007 - Elsevier
Extracellular stress proteins including heat shock proteins (Hsp) and glucose regulated
proteins (Grp) are emerging as important mediators of intercellular signaling and transport …