Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist's toolkit. Microglial morphological phenomics can be conducted …

Microglial cells play essential volume-related actions in the brain that contribute to the
maturation and plasticity of neural circuits that ultimately shape behavior. Microglia can thus …

Depression and anxiety commonly occur in chronic pain states and the coexistence of these
diseases worsens outcomes for both disorders and may reduce treatment adherence and …

Objectives: Obesity is a major epidemic in our population and has emerged as a primary
health concern. Consumption of a high fat, high sugar (HFHS) diet can specifically lead to …

Exposing animals to an enriched environment (EE) has dramatic effects on brain structure,
function, and plasticity. The poorly known" EE-derived signals''mediating the EE effects are …

Environmental enrichment (EE) is an experimental paradigm that is used to explore how a
complex, stimulating environment can impact overall health. In laboratory animal …

A large number of families worldwide suffer from the physical and mental burden posed by
stroke. An increasing number of studies aimed at the prevention and treatment of stroke …

Microglia are the resident immune cells of the adult brain that become activated in response
to pathogen-or damage-associated stimuli. The acute inflammatory response to injury …

Microglia, the innate immune cells of the brain, are commonly perceived as resident
macrophages of the central nervous system (CNS). This definition, however, requires further …