In recent years, remarkable advances in the ability to diagnose genetic disorders have been
made. The identification of disease-causing genes allows the development of gene-specific …

Since the development of the first docking program in 1982, the use of docking-based in
silico screening for potentially bioactive molecule discovery has become a common strategy …

The presence in the mRNA of premature stop codons (PTCs) results in protein truncation
responsible for several inherited (genetic) diseases. A well-known example of these …

Primary ciliary dyskinesia (PCD) is a rare disease with autosomal recessive inheritance,
caused mostly by bi-allelic gene mutations that impair motile cilia structure and function …

It is necessary to detect the biogenic amine (BA) content in food due to their toxicological
effects and their role as an index of freshness for protein-rich foods. Aptamer-based …

Single-stranded RNA aptamers have emerged as novel biosensor tools. However, the
immobilization procedure of the aptamer onto a surface generally induces a loss of affinity …

The interaction of positively-charged antibiotic gentamicin with cell membranes was studied
to determine if any changes in membrane organization were induced by the drug. Opossum …

Our awareness and appreciation of the many regulatory roles of RNA have dramatically
increased in the past decade. This understanding, in addition to the impact of RNA in many …

In addition to the already reported nukuhivensiums 1 and 2, 11 indole alkaloids were
isolated from the bark of the plant Rauvolfia nukuhivensis, growing in the Marquesas …

The highly flexible nature of RNA provides a formidable challenge for structure-based drug
design approaches that target RNA. We introduce an approach for modeling target …