Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

Significance: Mitochondria represent a major source of intracellular reactive oxygen species
(ROS) generation. This is often a consequence of oxidative phosphorylation, which can …

The incidence of type 2 diabetic osteoporosis (T2DOP), which seriously threatens elderly
people's health, is rapidly increasing in recent years. However, the specific mechanism of …

Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing
factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating …

Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …

Aging is associated with sarcopenia. The loss of strength results in decreased muscle mass
and motor function. This process accelerates the progressive muscle deterioration observed …

Significance: Reactive oxygen species (ROS) are now widely recognized as central
mediators of cell signaling. Mitochondria are major sources of ROS. Recent Advances: It is …