Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Covering: up to 2010 This review focuses on recent developments in the use of natural
products as therapeutics for Alzheimer's disease. The compounds span a diverse array of …

This review focuses on the specific biological effects of optically pure silymarin flavo-
nolignans, mainly silybins A and B, isosilybins A and B, silychristins A and B, and their 2, 3 …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

Introduction: 15-Lipoxygenases (15-LOXes) are a family of iron-containing proteins that
have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types …

This study demonstrates how regio-and diastereo-isomers with near-identical NMR spectra
can be distinguished and unambiguously assigned using quantum mechanical driven 1H …

Flavonoids are phytochemicals present in almost all terrestrial plants and, as a
consequence, in plant-based foods, and thus consumed by humans through diet. Recent …

A codrug of the anti-Alzheimer drug tacrine and the natural product silibinin was
synthesized. The codrug's biological and pharmacological properties were compared to an …

Modern medicinal chemistry has come to its bottleneck and is full of challenges, specially
when facing with long-term central nervous system (CNS) disorders induced by several …