Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …

Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …

N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Background Extant data from in vivo animal models and postmortem studies indicate that
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …

Oxidative stress is central to the pathology of several neurodegenerative diseases, including
multiple sclerosis, and therapeutics designed to enhance antioxidant potential could have …

Glutathione (GSH) is an important antioxidant found abundantly and synthesized
intracellularly in the cytosol in a tightly regulated fashion. It has diverse physiological …

Rapid increase in aging populations is an urgent problem because older adults are more
likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare …

Glutathione (GSH) was discovered in yeast cells in 1888. Studies of GSH in mammalian
cells before the 1980s focused exclusively on its function for the detoxication of xenobiotics …

We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …