The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-
gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion …

Research into the physiological actions of anti-Müllerian hormone (AMH) has rapidly
expanded from its classical role in male sexual differentiation to the regulation of ovarian …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

Mammalian reproductive cycles are controlled by an intricate interplay between the
hypothalamus, pituitary and gonads. Central to the function of this axis is the ability of the …

The pituitary gonadotropin hormones, FSH and LH, are essential for fertility. Containing an
identical α-subunit (CGA), they are comprised of unique β-subunits, FSHβ and LHβ …

The C (2) H (2) zinc-finger transcription factor Egr-1 has previously been shown to play an
essential role within the endocrine system as a molecular determinant of LH beta-subunit …

Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) and
hypogonadotropic hypogonadism (HHG). In affected boys, primary adrenal insufficiency …

Domesticated species have an attenuated behavioral and physiological stress response
compared to their wild counterparts, but the genetic mechanisms underlying this change are …

Recently, several cis-regulatory elements that play roles in LHβ gene expression, and their
cognate DNA-binding transcription factors, have been identified. These factors include Sp1 …

Normal gametogenesis and steroidogenesis is highly dependent on the pulsatile release of
hypothalamic GnRH that binds high-affinity receptors present at the surface of pituitary …