Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound
multiorgan effects. The low prevalence of SCD (∼ 100,000/US) has limited progress in …

Acute lung injury (ALI) and its most severe extreme the acute respiratory distress syndrome
(ARDS) refer to increased-permeability pulmonary edema caused by a variety of pulmonary …

Based on a prospective cohort study of 1056 patients with sickle cell anemia (Hb SS)
initiated in 1959, we investigated the influence of calendar era, age, sex, and prior medical …

The prevention and treatment of acute chest syndrome (ACS) is a major clinical concern in
sickle cell disease (SCD). However, the mechanism underlying the pathogenesis of ACS …

1Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, 2Lane Fox
Respiratory Unit, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust …

1Whittington Health, 2Barts Health NHS Trust & NHS Blood and Transplant, London,
3Oxford University Hospitals NHS Foundation Trust, Oxford, 4University College London …

Rationale: Steady-state mild pulmonary hypertension is a risk factor for death in adults with
sickle cell disease. Acute pulmonary hypertension has been reported during exercise and …

Background: Pulmonary complications are a major cause of morbidity and mortality in sickle
cell disease (SCD). The relationship of asthma with SCD and acute chest syndrome (ACS) …

The intermittent vascular occlusion occurring in sickle cell disease (SCD) leads to ischemia-
reperfusion injury and activation of inflammatory processes including enhanced production …

Acute chest syndrome (ACS) is a leading cause of respiratory distress and hospitalisation in
children with sickle cell disease (SCD). The aetiology is multifactorial and includes fat …