The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Mutations in the gene BEST1 are causally associated with as many as five clinically distinct
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …

The aging process is accompanied by the onset of disease and a general decline in
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …

We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …

Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic
variants impact cellular function in disease, as well as an emerging source of tissue for …

Improved methodologies for modeling cardiac disease phenotypes and accurately
screening the efficacy and toxicity of potential therapeutic compounds are actively being …

Stem cell aging is a process in which stem cells progressively lose their ability to self-renew
or differentiate, succumb to senescence or apoptosis, and eventually become functionally …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …

Simple Summary Lameness due to musculoskeletal disease is the most common diagnosis
in equine veterinary practice. Many of these orthopaedic disorders are chronic problems, for …

Abstract Human induced Pluripotent Stem Cells (iPSCs) have enormous potential in
understanding developmental biology, disease modeling, drug discovery, and regenerative …