Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …

Five hundred thirty-seven million people globally suffer from diabetes. Insulin-producing β
cells are reduced in number in most people with diabetes, but most individuals still have …

Islet transplantation has now become a promising treatment for insulin-deficient diabetes
mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous …

HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes
(HNF1A–maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic HNF1A …

The adrenal gland provides an important function by integrating neuronal, immune,
vascular, metabolic and endocrine signals under a common organ capsule. It is the central …

Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid
technologies have rapidly advanced, leading to the emergence of bioengineering islet …

Successful genome editing in primary human islets could reveal features of the genetic
regulatory landscape underlying β cell function and diabetes risk. Here, we describe a …

Background Transplantation of the human pancreatic islets is a promising approach for
specific types of diabetes to improve glycemic control. Although effective, there are several …

Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes
to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of …