Viruses depend on their hosts to complete their replication cycles; they exploit cellular
receptors for entry and hijack cellular functions to replicate their genome, assemble progeny …

Cellular functions are mediated by complex interactome networks of physical, biochemical,
and functional interactions between DNA sequences, RNA molecules, proteins, lipids, and …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …

The generation of organoids and tissues with programmable cellular complexity,
architecture and function would benefit from the simultaneous differentiation of human …

Identifying pathogenic variants and underlying functional alterations is challenging. To this
end, we introduce MutPred2, a tool that improves the prioritization of pathogenic amino acid …

Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …

Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …

Transcription is orchestrated by thousands of transcription factors (TFs) and chromatin-
associated proteins, but how these are causally connected to transcriptional activation is …