The evolutionarily conserved endosomal retromer complex rescues transmembrane
proteins from the lysosomal degradative pathway and facilitates their recycling to other …

The highly conserved fatty acid de novo synthesis pathway in mitochondria proceeds in an
acyl carrier protein-dependent manner through a discrete set of enzymes. Saccharomyces …

CHAF1B is the p60 subunit of the chromatin assembly factor (CAF1) complex, which is
responsible for assembly of histones H3. 1/H4 heterodimers at the replication fork during S …

Intracellular trafficking and protein sorting are mediated by various protein complexes, with
the retromer complex being primarily involved in retrograde traffic from the endosome or …

The membrane-trafficking system underpins cellular trafficking of material in eukaryotes and
its evolution would have been a watershed in eukaryogenesis. Evolutionary cell biological …

Endocytosis of ligand-activated plasma membrane receptors has been shown to contribute
to the regulation of their downstream signaling. β-arrestins interact with the phosphorylated …

Recent mass spectrometry maps of the human interactome independently support the
existence of a large multiprotein complex, dubbed" Commander." Broadly conserved across …

Down syndrome (DS) is the most common genetic cause of significant intellectual disability
in the human population, occurring in roughly 1 in 700 live births. The ultimate cause of DS …

Mammalian tissues display a remarkable complexity of splicing patterns. Nevertheless, only
few examples of tissue-specific splicing regulators are known. Herein, we characterize a …

Early endosomal cargo is typically targeted to either a degradative or recycling pathway.
Despite established functions for the retromer and ESCRT complexes at late endosomes …