During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

The genomic stability of all organisms depends on the precise partition of chromosomes to
daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores …

The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that
sister chromatids do not separate until all chromosomes are correctly bioriented during …

The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

In mitosis, for each daughter cell to inherit an accurate copy of the genome from the mother
cell, sister chromatids in the mother cell must attach to microtubules emanating from …

The mitotic checkpoint evolved to prevent cell division when chromosomes have not
established connections with the chromosome segregation machinery. Many of the …

Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the
monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that …

The kinetochore, the proteinaceous structure on the mitotic centromere, functions as a
mechanical latch that hooks onto microtubules to support directional movement of …