The spinocerebellar ataxias (SCAs) are a group of dominantly inherited diseases that share
the defining feature of progressive cerebellar ataxia. The disease process, however, is not …

There are over 40 autosomal dominant spinocerebellar ataxias (SCAs) now identified. In this
chapter we delineate the phenotypes of SCAs 1-44 and dentatorubral-pallidoluysian atrophy …

Spinocerebellar ataxias are dominantly inherited disorders that are associated with
progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of …

The cerebellum is crucial for both motor and nonmotor functions. Alzheimer's disease (AD),
alongside other dementias such as vascular dementia (VaD), Lewy body dementia (DLB) …

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases
mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One …

Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a progressive
autosomal dominantly inherited cerebellar ataxia characterized by the aggregation of …

Although white matter damage may play a major role in the pathogenesis of spinocerebellar
ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. In this …

Purpose Increasing neuroimaging studies have revealed gray matter (GM) and white matter
(WM) anomalies of several brain regions by voxel-based morphometry (VBM) studies on …

Abstract Spinocerebellar ataxias type 1 (SCA1) is an autosomal dominant disease usually
manifesting in adulthood. We performed a prospective 1-year longitudinal study in 14 …

Background and purpose Machado− Joseph disease (MJD/SCA 3) is the most frequent
spinocerebellar ataxia, characterized by brainstem, basal ganglia and cerebellar damage …