[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms

A Łabno, R Tomecki, A Dziembowski - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

[HTML][HTML] The control of mRNA decapping and P-body formation

TM Franks, J Lykke-Andersen - Molecular cell, 2008 - cell.com
mRNA decapping is a critical step in eukaryotic cytoplasmic mRNA turnover. Cytoplasmic
mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is …

mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription

K Brannan, H Kim, B Erickson, K Glover-Cutter, S Kim… - Molecular cell, 2012 - cell.com
We report a function of human mRNA decapping factors in control of transcription by RNA
polymerase II. Decapping proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 …

Regulation of mRNA decapping

Y Li, M Kiledjian - Wiley Interdisciplinary Reviews: RNA, 2010 - Wiley Online Library
Decapping is a critical step in the control of mRNA stability and the regulation of gene
expression. Two major decapping enzymes involved in mRNA turnover have been …

Structural and functional control of the eukaryotic mRNA decapping machinery

M Arribas-Layton, D Wu, J Lykke-Andersen… - Biochimica et Biophysica …, 2013 - Elsevier
The regulation of mRNA degradation is critical for proper gene expression. Many major
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …

Structural basis of dcp2 recognition and activation by dcp1

M She, CJ Decker, DI Svergun, A Round, N Chen… - Molecular cell, 2008 - cell.com
A critical step in mRNA degradation is the removal of the 5′ cap structure, which is
catalyzed by the Dcp1-Dcp2 complex. The crystal structure of an S. pombe Dcp1p-Dcp2n …

Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression

S Parrish, W Resch, B Moss - Proceedings of the National …, 2007 - National Acad Sciences
Previous studies indicated that the vaccinia virus D10 protein, which is conserved in all
sequenced poxviruses, participates in the rapid turnover of host and viral mRNAs. D10 …

mRNA decapping is promoted by an RNA-binding channel in Dcp2

MV Deshmukh, BN Jones, DU Quang-Dang, J Flinders… - Molecular cell, 2008 - cell.com
Cap hydrolysis by Dcp2 is a critical step in several eukaryotic mRNA decay pathways.
Processing requires access to cap-proximal nucleotides and the coordinated assembly of a …

Applications of phosphate modification and labeling to study (m) RNA caps

M Warminski, PJ Sikorski, J Kowalska… - Phosphate Labeling and …, 2017 - Springer
The cap is a natural modification present at the 5'ends of eukaryotic messenger RNA
(mRNA), which because of its unique structural features, mediates essential biological …

Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase

H Hashimi, Z Čičová, L Novotná, YZ Wen, J Lukeš - Rna, 2009 - rnajournal.cshlp.org
The mitochondrial RNA binding complex 1 (MRB1) is a recently discovered complex of
proteins associated with the TbRGG1 and TbRGG2 proteins in Trypanosoma brucei. Based …