The transition from a fetus to a newborn is the most complex physiologic adaptation that
occurs in human experience. Before medicalization of delivery, the transition had to occur …

Methods A working group from PPHNet specialists that included neonatologists,
cardiologists, pulmonologists, and intensivists was established to create this document …

Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

CHAIR: Costanzo MR: Midwest Heart Foundation, Lombard Illinois, USA TASK FORCE 1:
Dipchand A: Hospital for Sick Children, Toronto Ontario, Canada; Starling R: Cleveland …

In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has
evolved from a potential anti-angina drug to an on-demand oral treatment for erectile …

The management of congenital heart disease has changed dramatically over the last 15
years and continues to evolve at a rapid pace. More than ever before contemporary practice …

Introduction Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting
right ventricular (RV) failure occur in many critical illnesses and may be associated with a …

Pulmonary arterial hypertension (PAH) is often difficult to diagnose and challenging to treat.
Untreated, it is characterized by a progressive increase in pulmonary vascular resistance …

OBJECTIVE: To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic
guanosine monophosphate–specific phosphodiesterase, in treating near-term and term …

Background The application of iloprost, a stable prostacyclin analogue, by inhalation has
been shown to improve hemodynamic variables in patients with primary pulmonary …