Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

T DiTommaso, JM Cole, L Cassereau… - Proceedings of the …, 2018 - National Acad Sciences
The translational potential of cell-based therapies is often limited by complications related to
effectively engineering and manufacturing functional cells. While the use of electroporation …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Sonoporation: Past, present, and future

J Rich, Z Tian, TJ Huang - Advanced materials technologies, 2022 - Wiley Online Library
A surge of research in intracellular delivery technologies is underway with the increased
innovations in cell‐based therapies and cell reprogramming. Particularly, physical cell …

Materials for improving immune cell transfection

ARK Kumar, Y Shou, B Chan, A Tay - Advanced Materials, 2021 - Wiley Online Library
Chimeric antigen receptor T cell (CAR‐T) therapy holds great promise for preventing and
treating deadly diseases such as cancer. However, it remains challenging to transfect and …

Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials

P Zhang, N Shao, L Qin - Advanced Materials, 2021 - Wiley Online Library
Cell‐based living materials, including single cells, cell‐laden fibers, cell sheets, organoids,
and organs, have attracted intensive interests owing to their widespread applications in …

Automating CAR‐T transfection with micro and nano‐technologies

T Hu, ARK Kumar, Y Luo, A Tay - Small Methods, 2024 - Wiley Online Library
Cancer poses a significant health challenge, with traditional treatments like surgery,
radiotherapy, and chemotherapy often lacking in cell specificity and long‐term curative …

Controllable cell deformation using acoustic streaming for membrane permeability modulation

X Guo, M Sun, Y Yang, H Xu, J Liu, S He… - Advanced …, 2021 - Wiley Online Library
Hydrodynamic force loading platforms for controllable cell mechanical deformation play an
essential role in modern cell technologies. Current systems require assistance from specific …

High throughput and highly controllable methods for in vitro intracellular delivery

J Brooks, G Minnick, P Mukherjee, A Jaberi, L Chang… - Small, 2020 - Wiley Online Library
In vitro and ex vivo intracellular delivery methods hold the key for releasing the full potential
of tissue engineering, drug development, and many other applications. In recent years, there …