Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Abstract RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …

Coat protein complex I (COPI) vesicles mediate the retrograde transfer of cargo between
Golgi cisternae and from the Golgi to the endoplasmic reticulum (ER). However, their roles in …

Eukaryotic RNA polymerases (RNA pols) transcriptional processes have been extensively
investigated, and the structural analysis of eukaryotic RNA pols has been explored …

Gene expression is a complex phenomenon that depends on multiple protein complexes,
including RNA polymerases (RNA pols). In eukaryotes, bacteria, and archaea, RNA pols are …

Bud27 and its human orthologue URI (unconventional prefoldin RPB5-interactor) are
members of the prefoldin (PFD) family of ATP-independent molecular chaperones binding …

The transcriptional regulator MINIYO (IYO) is essential and rate-limiting for initiating cell
differentiation in Arabidopsis thaliana. Moreover, IYO moves from the cytosol into the …

RNA pol II assembly occurs in the cytoplasm before translocation of the enzyme to the
nucleus. Affecting this assembly influences mRNA transcription in the nucleus and mRNA …

Abstract RNA polymerase II (RNAPII) is an essential machinery for catalyzing mRNA
synthesis and controlling cell fate in eukaryotes. Although the structure and function of …

Rtr1 is an RNA polymerase II (RNA pol II) CTD-phosphatase that influences gene
expression during the transition from transcription initiation to elongation and during …